ABCD1 and ABCD2

Number of citations of the paper that reports this interaction (PubMedID 10551832)
26

Data Source:
HPRD (in vivo, two hybrid)

		ABCD1	ABCD2
Description		ATP binding cassette subfamily D member 1	ATP binding cassette subfamily D member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Peroxisome Peroxisomal Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding Fatty-acyl-CoA Transmembrane Transporter Activity ATPase Activity Enzyme Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Identical Protein Binding Protein Homodimerization Activity ADP Binding	Protein Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity
	Biological Process	Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Peroxisomal Long-chain Fatty Acid Import Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Transmembrane Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes adrenoleukodystrophy (ALD) Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import
Drugs
Diseases		Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS
Interacting Genes		6 interacting genes: ABCD2 ABCD3 ATP6AP1 PEX19 RPSA SLC27A2	3 interacting genes: ABCD1 ABCD3 PEX19
Entrez ID		215	225
HPRD ID		02300	03051
Ensembl ID		ENSG00000101986	ENSG00000173208
Uniprot IDs		P33897	Q9UBJ2
PDB IDs
Enriched GO Terms of Interacting Partners?
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