ATP6AP1 and SYVN1

Number of citations of the paper that reports this interaction (PubMedID 21987572)
35

Data Source:
BioGRID (enzymatic study)

		ATP6AP1	SYVN1
Description		ATPase H+ transporting accessory protein 1	synoviolin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase, V1 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding ATP Binding Rab GTPase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Cellular PH Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Positive Regulation Of ERK1 And ERK2 Cascade Proton Transmembrane Transport Positive Regulation Of Osteoclast Development	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol IRE1-mediated Unfolded Protein Response ERAD Pathway Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming
Pathways		Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport	XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS			Blood protein levels ( 28240269)
Interacting Genes		11 interacting genes: ABCD1 ANG CETN2 CTAG1B ERBB2 HBA1 LARP1 NR1I2 NT5E RHOU SYVN1	13 interacting genes: APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2G1 UBE2U UBE2Z USP7
Entrez ID		537	84447
HPRD ID		02184	07618
Ensembl ID		ENSG00000071553	ENSG00000162298
Uniprot IDs		A0A0C4DGX8 A0A384MQW4 Q15904	Q86TM6
PDB IDs			6A3Z
Enriched GO Terms of Interacting Partners?
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