FBL and MAP3K14

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
HPRD (in vitro)

		FBL	MAP3K14
Description		fibrillarin	mitogen-activated protein kinase kinase kinase 14
Image
GO Annotations	Cellular Component	Fibrillar Center Dense Fibrillar Component Granular Component Nucleus Nucleoplasm Chromosome Nucleolus Cajal Body Membrane Box C/D SnoRNP Complex Small-subunit Processome Extracellular Exosome	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	TFIID-class Transcription Factor Complex Binding RNA Binding Protein Binding RRNA Methyltransferase Activity ATPase Binding Histone-glutamine Methyltransferase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Box C/D SnoRNA 3'-end Processing Osteoblast Differentiation RRNA Processing RRNA Methylation SnoRNA Localization Histone Glutamine Methylation	MAPK Cascade Activation Of MAPKK Activity Immune Response I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK - noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		17 interacting genes: DDX17 DDX5 ERG KLF6 MAP3K14 PIN4 PRMT1 PRMT3 PRMT6 PSMB6 RUVBL1 RUVBL2 SMN1 SMN2 SNRPN TAF9 TBC1D17	40 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91
Entrez ID		2091	9020
HPRD ID		00617	05230
Ensembl ID		ENSG00000105202	ENSG00000006062
Uniprot IDs		P22087	Q68D39 Q99558
PDB IDs		2IPX	4DN5 4G3D 4IDT 4IDV
Enriched GO Terms of Interacting Partners?
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