EIF1AX and EIF5

Number of citations of the paper that reports this interaction (PubMedID 10982835)
35

Data Source:
HPRD (in vitro, in vivo)

		EIF1AX	EIF5
Description		eukaryotic translation initiation factor 1A X-linked	eukaryotic translation initiation factor 5
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GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding	RNA Binding Translation Initiation Factor Activity GTPase Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Translational Initiation	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Activation Of GTPase Activity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		8 interacting genes: APP EIF2S1 EIF3C EIF5 EIF5B HSPB1 IKBKG IPO13	15 interacting genes: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1
Entrez ID		1964	1983
HPRD ID		02174	03417
Ensembl ID		ENSG00000173674	ENSG00000100664
Uniprot IDs		P47813	A0A024R6Q1 P55010
PDB IDs		1D7Q 3ZJY 4KZY 4KZZ	2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?
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