EIF5 and NRGN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		EIF5	NRGN
Description		eukaryotic translation initiation factor 5	neurogranin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Trans-Golgi Network Transport Vesicle Membrane Postsynaptic Density Axon Mitochondrial Membrane Neuronal Cell Body Dendritic Spine Head Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	RNA Binding Translation Initiation Factor Activity GTPase Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidic Acid Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Activation Of GTPase Activity	Signal Transduction Nervous System Development Associative Learning Telencephalon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Long-term potentiation Long-term potentiation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 28991256 25056061 19571808 29483656 30285260)
Interacting Genes		15 interacting genes: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1	6 interacting genes: CALM1 EIF5 GLP1R PRKCA PRKCB PRKCG
Entrez ID		1983	4900
HPRD ID		03417	03828
Ensembl ID		ENSG00000100664	ENSG00000154146
Uniprot IDs		A0A024R6Q1 P55010	A0A024R3M7 Q92686
PDB IDs		2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?
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