LPAR1 and GNAI3

Number of citations of the paper that reports this interaction (PubMedID 9600933)
59

Data Source:
HPRD (in vitro)

		LPAR1	GNAI3
Description		lysophosphatidic acid receptor 1	G protein subunit alpha i3
Image
GO Annotations	Cellular Component	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Neuronal Cell Body Dendritic Spine Dendritic Shaft	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding PDZ Domain Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Oligodendrocyte Development Cerebellum Development Optic Nerve Development Corpus Callosum Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis Positive Regulation Of Dendritic Spine Development Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis Cellular Response To 1-oleoyl-sn-glycerol 3-phosphate	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) Central corneal thickness ( 31798171 29760442 30894546) Corneal structure ( 23291589) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 20881960 25282103 31562340) Monocyte count ( 28193307 29403010) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Post bronchodilator FEV1 in COPD ( 26634245) Pursuit maintenance gain ( 29064472) Sum eosinophil basophil counts ( 27863252) White blood cell count (monocyte) ( 28158719)	Major depressive disorder ( 20125088)
Interacting Genes		6 interacting genes: ARHGEF11 ARHGEF12 GIPC1 GNAI3 KRAS SLC9A3R2	41 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		1902	2773
HPRD ID		03790	00765
Ensembl ID		ENSG00000198121	ENSG00000065135
Uniprot IDs		Q5VZX0 Q92633	P08754
PDB IDs		4Z34 4Z35 4Z36	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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