GNAI3 and SOX30

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GNAI3	SOX30
Description		G protein subunit alpha i3	SRY-box transcription factor 30
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome	Nuclear Chromatin Nucleus Cytoplasm Chromocenter
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Beta-catenin Binding Sequence-specific DNA Binding
	Biological Process	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Spermatid Development Negative Regulation Of Wnt Signaling Pathway Response To Corticosteroid Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Glycated hemoglobin levels ( 28898252) Triglyceride levels ( 31647587)
Interacting Genes		41 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	18 interacting genes: AHCYL1 AURKA BAMBI BRCA1 CFAP206 CUL5 DCAF4 DDX56 FBXO38 FLI1 GNAI3 GP2 KIFC3 MRPS5 NME1 NUDT3 PAXIP1 TRAF2
Entrez ID		2773	11063
HPRD ID		00765	09461
Ensembl ID		ENSG00000065135	ENSG00000039600
Uniprot IDs		P08754	B4DXW7 O94993
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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