GNAI3 and RANGAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GNAI3	RANGAP1
Description		G protein subunit alpha i3	Ran GTPase activating protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Aggresome Dendrite Nuclear Membrane Intracellular Membrane-bounded Organelle Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	RNA Binding GTPase Activator Activity Protein Binding Ran GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Signal Transduction Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Activation Of GTPase Activity Cellular Response To Vasopressin
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Heel bone mineral density ( 30598549) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		41 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	16 interacting genes: CCL5 CSNK2A1 GNAI1 GNAI3 IPO8 PRKACA RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1
Entrez ID		2773	5905
HPRD ID		00765	03839
Ensembl ID		ENSG00000065135	ENSG00000100401
Uniprot IDs		P08754	A0A024R1U0 P46060 Q9BSK3
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M
Enriched GO Terms of Interacting Partners?
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