DSP and KRT5

Number of citations of the paper that reports this interaction (PubMedID 7525601)
61

Data Source:
HPRD (in vitro, in vivo)

		DSP	KRT5
Description		desmoplakin	keratin 5
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	Nucleus Cytoplasm Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome
	Molecular Function	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Adherens Junction Organization Wound Healing Neutrophil Degranulation Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs		Zinc Artenimol	Zinc
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic	Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Idiopathic pulmonary fibrosis ( 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)	Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		30 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDH5 COL17A1 CSTA DES DSC1 EVPL GRPEL1 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM	17 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 TCHP UBE3A
Entrez ID		1832	3852
HPRD ID		00513	01010
Ensembl ID		ENSG00000096696	ENSG00000186081
Uniprot IDs		B4DKX6 P15924 Q4LE79	P13647
PDB IDs		1LM5 1LM7 3R6N 5DZZ	3TNU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?