ATN1 and DMPK

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATN1	DMPK
Description		atrophin 1	DM1 protein kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm	Cell Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Neuron Apoptotic Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synapse Structural Plasticity Regulation Of Cardiac Conduction
Pathways		Regulation of PTEN gene transcription	Ion homeostasis
Drugs			3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
Diseases		Dentatorubropallidoluysian atrophy (DRPLA)	Myotonic dystrophy (DM)
GWAS			Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		93 interacting genes: AGRN ALG13 ARF3 ATRX BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CTNND2 DMPK DVL1 DVL2 ECM1 EFEMP1 EFEMP2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HINFP HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP4-12 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 PCSK5 PDCD6IP PFKL PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SIAH1 SIAH2 SLIT1 SPAG5 SSPOP STXBP4 SYVN1 TEP1 TLE1 TLE5 TRIP6 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZSWIM8	19 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A PVR RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		1822	1760
HPRD ID		06311	05645
Ensembl ID		ENSG00000111676	ENSG00000104936
Uniprot IDs		P54259 Q86V38	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs			1WT6 2VD5
Enriched GO Terms of Interacting Partners?
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