DMPK and HOXA2

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		DMPK	HOXA2
Description		DM1 protein kinase	homeobox A2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synapse Structural Plasticity Regulation Of Cardiac Conduction	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Determination Osteoblast Development Segment Specification Motor Neuron Axon Guidance Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Rhombomere 2 Development Rhombomere 3 Morphogenesis Brain Segmentation Middle Ear Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Viscerocranium Morphogenesis Cellular Response To Retinoic Acid
Pathways		Ion homeostasis	Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of expression of SLITs and ROBOs
Drugs		3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
Diseases		Myotonic dystrophy (DM)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)	Chronic venous disease ( 28374850) Tonsillectomy ( 27182965 28928442)
Interacting Genes		19 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A PVR RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4	5 interacting genes: DMPK MEIS1 NDE1 RALA RCHY1
Entrez ID		1760	3199
HPRD ID		05645	05252
Ensembl ID		ENSG00000104936	ENSG00000105996
Uniprot IDs		B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013	O43364
PDB IDs		1WT6 2VD5
Enriched GO Terms of Interacting Partners?
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