TSC22D1 and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TSC22D1	DDAH2
Description		TSC22 domain family member 1	dimethylarginine dimethylaminohydrolase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Cytosol Centriolar Satellite Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Catalytic Activity Protein Binding Dimethylargininase Activity Amino Acid Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II	Citrulline Metabolic Process Arginine Metabolic Process Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity
Pathways			eNOS activation
Drugs			L-Citrulline
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Rosacea symptom severity ( 29771307)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		50 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GTF2F2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	22 interacting genes: ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 GADD45G MAP3K20 MKNK1 PIN1 RAP1B RCC1 RPS6KA1 RPS6KA5 SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		8848	23564
HPRD ID		07414	09204
Ensembl ID		ENSG00000102804	ENSG00000213722
Uniprot IDs		A0A024RDV8 A0A087X0H8 A8K3Y6 Q15714	O95865 V9HW53
PDB IDs
Enriched GO Terms of Interacting Partners?
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