DNASE1 and ACTA2

Number of citations of the paper that reports this interaction (PubMedID 11707283)
2

Data Source:
HPRD (in vitro)

		DNASE1	ACTA2
Description		deoxyribonuclease 1	actin alpha 2, smooth muscle
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	DNA Binding Actin Binding Deoxyribonuclease I Activity Deoxyribonuclease Activity Protein Binding	ATP Binding Protein Kinase Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Catabolic Process Apoptotic Process Regulation Of Neutrophil Mediated Cytotoxicity	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration
Pathways			Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription
Drugs			Phenethyl Isothiocyanate
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Body mass index ( 29273807)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)
Interacting Genes		4 interacting genes: ACTA1 ACTA2 ACTB ACTG1	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		1773	59
HPRD ID		00509	00031
Ensembl ID		ENSG00000213918	ENSG00000107796
Uniprot IDs		P24855	D2JYH4 P62736
PDB IDs		4AWN
Enriched GO Terms of Interacting Partners?
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