ACTA2 and CCT5

Number of citations of the paper that reports this interaction (PubMedID 11580270)
18

Data Source:
HPRD (in vitro)

		ACTA2	CCT5
Description		actin alpha 2, smooth muscle	chaperonin containing TCP1 subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome	Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome
	Molecular Function	ATP Binding Protein Kinase Binding	MRNA 3'-UTR Binding Protein Binding ATP Binding G-protein Beta-subunit Binding MRNA 5'-UTR Binding Beta-tubulin Binding Unfolded Protein Binding
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration	Protein Folding Binding Of Sperm To Zona Pellucida Response To Virus Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Phenethyl Isothiocyanate
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)	Metabolite levels ( 23823483) Pain ( 22956598)
Interacting Genes		18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1	18 interacting genes: ACTA1 ACTA2 ACTB CDC20 DUXAP9 ELP1 HDAC3 IMMT MCPH1 PDCL SUMO4 TBC1D17 TCP1 TERT THEG TP53 XRN1 ZNRD2
Entrez ID		59	22948
HPRD ID		00031	06468
Ensembl ID		ENSG00000107796	ENSG00000150753
Uniprot IDs		D2JYH4 P62736	B4DDU6 B4DX08 B4DYC8 B7ZAR1 E7ENZ3 E9PCA1 P48643 V9HW37
PDB IDs			5UYX 5UYZ 6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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