ACTA2 and SELE

Number of citations of the paper that reports this interaction (PubMedID 8609175)
31

Data Source:
BioGRID (pull down)

		ACTA2	SELE
Description		actin alpha 2, smooth muscle	selectin E
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding Protein Kinase Binding	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription	Cell surface interactions at the vascular wall
Drugs		Phenethyl Isothiocyanate	Carvedilol N-acetyl-alpha-neuraminic acid
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919)
Interacting Genes		18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1	14 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 VCL
Entrez ID		59	6401
HPRD ID		00031	00566
Ensembl ID		ENSG00000107796	ENSG00000007908
Uniprot IDs		D2JYH4 P62736	P16581
PDB IDs			1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK
Enriched GO Terms of Interacting Partners?
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