CYP2C9 and CYP2D6

Number of citations of the paper that reports this interaction (PubMedID 19448135)
24

Data Source:
BioGRID (pull down)

		CYP2C9	CYP2D6
Description		cytochrome P450 family 2 subfamily C member 9	cytochrome P450 family 2 subfamily D member 6
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity Aromatase Activity	Monooxygenase Activity Iron Ion Binding Drug Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Amide Metabolic Process Icosanoid Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Retinol Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidation-reduction Process Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs
Drugs		4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One Heme C Diacerein Benzbromarone	Paliperidone Diacerein
Diseases
GWAS		Blood metabolite levels ( 24816252) Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499 26265036)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Intelligence ( 28530673) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Schizophrenia ( 25056061 29483656) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	3 interacting genes: CYB5A CYP2C9 POR
Entrez ID		1559	1565
HPRD ID		03084	00487
Ensembl ID		ENSG00000138109	ENSG00000100197
Uniprot IDs		P11712 S5RV20	C1ID52 P10635 Q5Y7H2
PDB IDs		1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI	2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU 6CSB 6CSD
Enriched GO Terms of Interacting Partners?
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