CYP2D6

Description		cytochrome P450 family 2 subfamily D member 6
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Retinol Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidation-reduction Process Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process
Pathways		Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs
Drugs		Paliperidone Diacerein
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Intelligence ( 28530673) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Schizophrenia ( 25056061 29483656) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		3 interacting genes: CYB5A CYP2C9 POR
Entrez ID		1565
HPRD ID		00487
Ensembl ID		ENSG00000100197
Uniprot IDs		C1ID52 P10635 Q5Y7H2
PDB IDs		2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU 6CSB 6CSD
Enriched GO Terms of Interacting Partners?
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