CYP2C9 and CYP3A4

Number of citations of the paper that reports this interaction (PubMedID 20215413)
24

Data Source:
BioGRID (pull down)

		CYP2C9	CYP3A4
Description		cytochrome P450 family 2 subfamily C member 9	cytochrome P450 family 3 subfamily A member 4
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity Aromatase Activity	Monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxygen Binding Enzyme Binding Heme Binding Vitamin D3 25-hydroxylase Activity Caffeine Oxidase Activity Quinine 3-monooxygenase Activity Testosterone 6-beta-hydroxylase Activity Aromatase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity 1,8-cineole 2-exo-monooxygenase Activity
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Amide Metabolic Process Icosanoid Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Lipid Hydroxylation Lipid Metabolic Process Steroid Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Heterocycle Metabolic Process Oxidation-reduction Process Oxidative Demethylation
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs
Drugs		4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One Heme C Diacerein Benzbromarone	Glutathione Isoniazid Paliperidone Pradefovir Mesylate Diacerein
Diseases
GWAS		Blood metabolite levels ( 24816252) Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499 26265036)	Metabolic traits ( 21886157) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Pre-treatment viral load in HIV-1 infection ( 31219150) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)
Interacting Genes		10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	8 interacting genes: CYB5A CYP2C9 GK POR PRKACA PRKCA STUB1 UGT2B7
Entrez ID		1559	1576
HPRD ID		03084	00484
Ensembl ID		ENSG00000138109	ENSG00000160868
Uniprot IDs		P11712 S5RV20	P08684 Q6GRK0
PDB IDs		1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI	1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R 5G5J 5TE8 5VC0 5VCC 5VCD 5VCE 5VCG 6BCZ 6BD5 6BD6 6BD7 6BD8 6BDH 6BDI 6BDK 6BDM 6OO9 6OOA 6OOB
Enriched GO Terms of Interacting Partners?
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