CYBB and NCF2

Number of citations of the paper that reports this interaction (PubMedID 11893732)
95

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CYBB	NCF2
Description		cytochrome b-245 beta chain	neutrophil cytosolic factor 2
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GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Acrosomal Vesicle Cell Nucleolus Cytosol Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Rac GTPase Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Defense Response Inflammatory Response Electron Transport Chain Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Oxidation-reduction Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Cellular Response To Oxidative Stress Superoxide Anion Generation Positive Regulation Of Catalytic Activity Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Oxidation-reduction Process
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		6 interacting genes: ACTG1 CYBA IQGAP1 NCF2 NCF4 RAC1	14 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		1536	4688
HPRD ID		02382	01991
Ensembl ID		ENSG00000165168	ENSG00000116701
Uniprot IDs		A0A0S2Z3S6 P04839	A0A0S2Z457 P19878
PDB IDs		3A1F	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?
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