CYBB and CYBA

Number of citations of the paper that reports this interaction (PubMedID 11893732)
95

Data Source:
HPRD (in vitro, in vivo)

		CYBB	CYBA
Description		cytochrome b-245 beta chain	cytochrome b-245 alpha chain
Image
GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Stress Fiber Cell Nucleus Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding	Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Defense Response Inflammatory Response Electron Transport Chain Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Oxidation-reduction Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Electron Transport Chain Positive Regulation Of Cell Growth Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Oxidation-reduction Process Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Gamma Radiation Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To L-glutamine
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		6 interacting genes: ACTG1 CYBA IQGAP1 NCF2 NCF4 RAC1	13 interacting genes: APPBP2 CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2
Entrez ID		1536	1535
HPRD ID		02382	01989
Ensembl ID		ENSG00000165168	ENSG00000051523
Uniprot IDs		A0A0S2Z3S6 P04839	B4DT46 H3BNP7 P13498
PDB IDs		3A1F	1WLP
Enriched GO Terms of Interacting Partners?
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