NCF2 and SYTL1

Number of citations of the paper that reports this interaction (PubMedID 11278853)
20

Data Source:
HPRD (in vitro)

		NCF2	SYTL1
Description		neutrophil cytosolic factor 2	synaptotagmin like 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cell Nucleolus Cytosol Membrane Phagolysosome NADPH Oxidase Complex	Plasma Membrane Extrinsic Component Of Plasma Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Rac GTPase Binding	Protein Binding Rab GTPase Binding Neurexin Family Protein Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Cellular Response To Oxidative Stress Superoxide Anion Generation Positive Regulation Of Catalytic Activity Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Oxidation-reduction Process	Intracellular Protein Transport Exocytosis
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	TBC/RABGAPs
Drugs		Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		14 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1	7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A
Entrez ID		4688	84958
HPRD ID		01991	12156
Ensembl ID		ENSG00000116701	ENSG00000142765
Uniprot IDs		A0A0S2Z457 P19878	Q8IYJ3
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?
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