TMEM199 and ERLIN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TMEM199	ERLIN1
Description		transmembrane protein 199	ER lipid raft associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Cholesterol Binding Ubiquitin Protein Ligase Binding
	Biological Process	Cellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process	Cholesterol Metabolic Process Ubiquitin-dependent ERAD Pathway SREBP Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Transmembrane Transport
Pathways			ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		3 interacting genes: ERLIN1 KASH5 LMNA	4 interacting genes: AGR3 FA2H SEC22A TMEM199
Entrez ID		147007	10613
HPRD ID		12679	08502
Ensembl ID		ENSG00000244045	ENSG00000107566
Uniprot IDs		Q8N511	O75477
PDB IDs
Enriched GO Terms of Interacting Partners?
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