RPP25L and ARHGEF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RPP25L	ARHGEF2
Description		ribonuclease P/MRP subunit p25 like	Rho/Rac guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Podosome Cell Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Bicellular Tight Junction Focal Adhesion Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	RNA Binding Protein Binding	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Rho GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding
	Biological Process		Establishment Of Mitotic Spindle Orientation Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Podosome Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858)
Interacting Genes		6 interacting genes: ARHGEF2 KLHL12 MID2 PNMA1 POP7 RPGRIP1	12 interacting genes: CGN MARK3 PAK1 PTPRF RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		138716	9181
HPRD ID		12948	10458
Ensembl ID		ENSG00000164967	ENSG00000116584
Uniprot IDs		Q8N5L8	A0A5F9ZI21 Q92974
PDB IDs			5EFX
Enriched GO Terms of Interacting Partners?
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