ARHGEF2 and CGN

Number of citations of the paper that reports this interaction (PubMedID 15866167)
80

Data Source:
HPRD (in vivo, in vitro)

		ARHGEF2	CGN
Description		Rho/Rac guanine nucleotide exchange factor 2	cingulin
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cell Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Bicellular Tight Junction Focal Adhesion Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Rho GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding	Motor Activity Actin Binding Protein Binding Cadherin Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Podosome Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration	Transforming Growth Factor Beta Receptor Signaling Pathway Biological_process
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858)	Body mass index ( 26426971)
Interacting Genes		12 interacting genes: CGN MARK3 PAK1 PTPRF RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAQ YWHAZ	6 interacting genes: ARHGEF2 F11R LNX1 TJP1 TJP2 YWHAG
Entrez ID		9181	57530
HPRD ID		10458	10827
Ensembl ID		ENSG00000116584	ENSG00000143375
Uniprot IDs		A0A5F9ZI21 Q92974	Q9P2M7
PDB IDs		5EFX
Enriched GO Terms of Interacting Partners?
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