ARHGEF2 and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 12384139)
48

Data Source:
HPRD (in vitro)

		ARHGEF2	RRAS2
Description		Rho/Rac guanine nucleotide exchange factor 2	RAS related 2
Image
GO Annotations	Cellular Component	Podosome Cell Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Bicellular Tight Junction Focal Adhesion Cytoplasmic Vesicle Vesicle Ruffle Membrane Protein-containing Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Transcription Factor Binding Zinc Ion Binding Rho GTPase Binding Rac Guanyl-nucleotide Exchange Factor Activity Rac GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Cell Morphogenesis Intracellular Protein Transport Actin Filament Organization Negative Regulation Of Microtubule Depolymerization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Asymmetric Neuroblast Division Negative Regulation Of Necroptotic Process Cellular Response To Muramyl Dipeptide Cellular Response To Tumor Necrosis Factor Cellular Hyperosmotic Response Negative Regulation Of Podosome Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Neuron Migration	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neuritic plaque ( 31497858)	Alzheimer's disease (cognitive decline) ( 23535033) Height ( 31562340) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Vitamin D levels ( 25208829)
Interacting Genes		12 interacting genes: CGN MARK3 PAK1 PTPRF RAC1 RHOA RPP25L RRAS2 YWHAE YWHAG YWHAQ YWHAZ	29 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		9181	22800
HPRD ID		10458	02518
Ensembl ID		ENSG00000116584	ENSG00000133818
Uniprot IDs		A0A5F9ZI21 Q92974	P62070
PDB IDs		5EFX	2ERY
Enriched GO Terms of Interacting Partners?
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