CR2 and CD19

Number of citations of the paper that reports this interaction (PubMedID 1702139)
51

Data Source:
HPRD (in vivo)

		CR2	CD19
Description		complement C3d receptor 2	CD19 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome	Cell Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Classical Pathway B Cell Differentiation Regulation Of Complement Activation B Cell Proliferation Innate Immune Response Viral Entry Into Host Cell	B-1 B Cell Differentiation B Cell Proliferation Involved In Immune Response Immunoglobulin Mediated Immune Response Regulation Of Complement Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling
Pathways		Regulation of Complement cascade	PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Blinatumomab Tisagenlecleucel Axicabtagene ciloleucel
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53	21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2
Entrez ID		1380	930
HPRD ID		00399	00113
Ensembl ID		ENSG00000117322	ENSG00000177455
Uniprot IDs		P20023	P15391
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED	6AL5
Enriched GO Terms of Interacting Partners?
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