CD19 and VAV2

Number of citations of the paper that reports this interaction (PubMedID 11080163)
21

Data Source:
HPRD (in vivo, in vitro)

		CD19	VAV2
Description		CD19 molecule	vav guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein-containing Complex Membrane Raft Extracellular Exosome	Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	B-1 B Cell Differentiation B Cell Proliferation Involved In Immune Response Immunoglobulin Mediated Immune Response Regulation Of Complement Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling	Angiogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Blinatumomab Tisagenlecleucel Axicabtagene ciloleucel
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) vWF and FVIII levels ( 21810271)
Interacting Genes		21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2	64 interacting genes: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MRGBP NCKAP5 NEK3 NUP214 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 STOM SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1
Entrez ID		930	7410
HPRD ID		00113	02694
Ensembl ID		ENSG00000177455	ENSG00000160293
Uniprot IDs		P15391	P52735
PDB IDs		6AL5	2DLZ 2DM1 2LNW 2LNX 4ROJ
Enriched GO Terms of Interacting Partners?
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