HAUS1 and MED4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		HAUS1	MED4
Description		HAUS augmin like complex subunit 1	mediator complex subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Cytosol Microtubule HAUS Complex	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Molecular_function Protein Binding	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		68 interacting genes: AK8 ARFIP2 BLOC1S6 C3orf62 CAGE1 CBY2 CCDC114 CCDC136 CCDC57 CCHCR1 CDR2 CEP170P1 CEP44 CEP55 CEP57L1 CEP63 CEP70 DCTN2 DMD DTNBP1 FGFR1OP2 GOLGA2 HOOK2 IFIT3 IFT20 INCA1 KDM1A KIFC3 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KXD1 LDOC1 LURAP1 MAD1L1 MAGEA6 MCM10 MCM3 MED4 MED7 MIPOL1 MTUS2 NDC80 NECAB2 NINL NUP54 NUP62 PDE4DIP PIBF1 SPAG5 STX11 SYCE1 SYCE3 TFIP11 TFPT TRAF1 TRIM23 TRIM27 TRIM54 TRIM69 TSG101 USHBP1 VPS52 WASHC3 ZNF471	33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		115106	29079
HPRD ID		16385	16145
Ensembl ID		ENSG00000152240	ENSG00000136146
Uniprot IDs		Q96CS2	A0A024RDY7 Q9NPJ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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