MED4 and NDE1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		MED4	NDE1
Description		mediator complex subunit 4	nudE neurodevelopment protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Kinetochore Condensed Chromosome Kinetochore Cell Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow Synapse
	Molecular Function	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Neuron Migration Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Neuroblast Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Cerebral Cortex Development Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1	27 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398
Entrez ID		29079	54820
HPRD ID		16145	14815
Ensembl ID		ENSG00000136146	ENSG00000072864
Uniprot IDs		A0A024RDY7 Q9NPJ6	Q9NXR1 X5DP35 X5DR54
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?