B4GALT7 and RABGGTB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		B4GALT7	RABGGTB
Description		beta-1,4-galactosyltransferase 7	Rab geranylgeranyltransferase subunit beta
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane Golgi Cisterna Membrane	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Binding Galactosyltransferase Activity Manganese Ion Binding Xylosylprotein 4-beta-galactosyltransferase Activity	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Rab GTPase Binding
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Cellular Protein Modification Process Protein N-linked Glycosylation Glycosaminoglycan Metabolic Process Negative Regulation Of Fibroblast Proliferation Supramolecular Fiber Organization	Cellular Protein Modification Process Visual Perception Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Defective B4GALT7 causes EDS, progeroid type	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs			N-Formylmethionine FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Ehlers-Danlos syndrome, progeroid form
GWAS		Blood protein levels ( 30072576) Methadone dose in opioid dependence ( 28115739) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		3 interacting genes: KRTAP10-3 KRTAP10-7 RABGGTB	16 interacting genes: ALAS2 ARAF B4GALT7 CHML PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A TAFA1 TMEM25 WDR4
Entrez ID		11285	5876
HPRD ID		05060	01532
Ensembl ID		ENSG00000027847	ENSG00000137955
Uniprot IDs		B3KMT1 Q9UBV7	A8KAJ2 P53611 Q6IB63
PDB IDs		4IRP 4IRQ	6O60
Enriched GO Terms of Interacting Partners?
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