RABGGTB and ARAF

Number of citations of the paper that reports this interaction (PubMedID 12620389)
11

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RABGGTB	ARAF
Description		Rab geranylgeranyltransferase subunit beta	A-Raf proto-oncogene, serine/threonine kinase
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Cellular_component Mitochondrion Cytosol
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Rab GTPase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification	MAPK Cascade Cellular Protein Modification Process Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		N-Formylmethionine FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate	ATP
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		16 interacting genes: ALAS2 ARAF B4GALT7 CHML PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A TAFA1 TMEM25 WDR4	59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG YWHAZ
Entrez ID		5876	369
HPRD ID		01532	02405
Ensembl ID		ENSG00000137955	ENSG00000078061
Uniprot IDs		A8KAJ2 P53611 Q6IB63	A0A024R178 P10398 Q96II5
PDB IDs		6O60	1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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