NOXA1 and MAPK11

Number of citations of the paper that reports this interaction (PubMedID 20110267)
20

Data Source:
BioGRID (enzymatic study)

		NOXA1	MAPK11
Description		NADPH oxidase activator 1	mitogen-activated protein kinase 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol NADPH Oxidase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Rac GTPase Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Positive Regulation Of Catalytic Activity Regulation Of Respiratory Burst	Activation Of MAPK Activity Ras Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Interleukin-12 Secretion
Pathways		RHO GTPases Activate NADPH Oxidases WNT5:FZD7-mediated leishmania damping	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation
Drugs			KC706 Regorafenib
Diseases
GWAS		Response to fenofibrate (total cholesterol levels) ( 27002377)	Acne (severe) ( 24927181)
Interacting Genes		14 interacting genes: CACNA1A EP300 FAT1 MAPK1 MAPK11 NCF1 NOX1 NOXO1 PRKACA PRKCA PRKCG RAC1 RAC2 RIMBP3	27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		10811	5600
HPRD ID		17644	04208
Ensembl ID		ENSG00000188747	ENSG00000185386
Uniprot IDs		Q86UR1	Q15759
PDB IDs			3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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