MAPK11 and ELK4

Number of citations of the paper that reports this interaction (PubMedID 9235954)
28

Data Source:
HPRD (in vitro)

		MAPK11	ELK4
Description		mitogen-activated protein kinase 11	ETS transcription factor ELK4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Ras Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Interleukin-12 Secretion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3 Deacetylation
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation
Drugs		KC706 Regorafenib
Diseases			Prostate cancer
GWAS		Acne (severe) ( 24927181)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	11 interacting genes: BRCA1 FOS ID1 ID2 ID3 MAPK1 MAPK11 MAPK3 MAPK7 MAPK8 SRF
Entrez ID		5600	2005
HPRD ID		04208	02592
Ensembl ID		ENSG00000185386	ENSG00000158711
Uniprot IDs		Q15759	A0A024R985 A0A024R997 P28324 Q8IXL1
PDB IDs		3GC8 3GC9 3GP0	1BC7 1BC8 1HBX 1K6O
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?