TRIM21 and PFKP

Number of citations of the paper that reports this interaction (PubMedID 29038421)
21

Data Source:
BioGRID (enzymatic study)

		TRIM21	PFKP
Description		tripartite motif containing 21	phosphofructokinase, platelet
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Extracellular Exosome
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding	6-phosphofructokinase Activity ATP Binding AMP Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Monosaccharide Binding Fructose-6-phosphate Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Interferon-gamma Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Fructose 6-phosphate Metabolic Process Glucose Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Protein Homotetramerization Canonical Glycolysis Cellular Response To Leukemia Inhibitory Factor
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation	Glycolysis
Drugs
Diseases
GWAS		Lung cancer ( 28604730)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Disc degeneration (lumbar) ( 22993228) Hippocampal volume in mild cognitive impairment ( 29274321) Scalp hair shape ( 26926045) Subclinical trait of interstitial lung disease (percentage of high attenuation areas on CT scan) ( 28521775)
Interacting Genes		52 interacting genes: APC CALR CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GABARAP GABARAPL1 GABARAPL2 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SKP2 SQSTM1 TBK1 TRIM27 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 YWHAZ	11 interacting genes: ACD AGO2 AKT1 DYNLL1 EGFR KAT5 POT1 TERF1 TINF2 TRIM21 WNK1
Entrez ID		6737	5214
HPRD ID		00170	01384
Ensembl ID		ENSG00000132109	ENSG00000067057
Uniprot IDs		P19474	B1APP6 Q01813
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53	4RH3 4U1R 4WL0 4XYJ 4XYK 4XZ2
Enriched GO Terms of Interacting Partners?
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