CDX2 and DNMT3L

Number of citations of the paper that reports this interaction (PubMedID 24952347)
9

Data Source:
BioGRID (pull down)

		CDX2	DNMT3L
Description		caudal type homeobox 2	DNA methyltransferase 3 like
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GO Annotations	Cellular Component	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcriptional Repressor Complex	Nucleus Cytosol ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Methyl-CpG Binding	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Endosome To Lysosome Transport Embryo Development Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation
Pathways		Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	DNA methylation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		14 interacting genes: ACAT2 CDK2 CREBBP DNMT3L EP300 GSK3B HNF1A MAPK1 MAPK14 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB	77 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1
Entrez ID		1045	29947
HPRD ID		02622	09417
Ensembl ID		ENSG00000165556	ENSG00000142182
Uniprot IDs		Q99626	Q9UJW3
PDB IDs		5LTY 6ES2 6ES3	2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57
Enriched GO Terms of Interacting Partners?
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