DNMT3L and NR1I3

Number of citations of the paper that reports this interaction (PubMedID 24952347)
9

Data Source:
BioGRID (pull down)

		DNMT3L	NR1I3
Description		DNA methyltransferase 3 like	nuclear receptor subfamily 1 group I member 3
Image
GO Annotations	Cellular Component	Nucleus Cytosol ESC/E(Z) Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Signal Transduction Multicellular Organism Development Cell Differentiation Intracellular Receptor Signaling Pathway Response To Lipid Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Lipopolysaccharide
Pathways		DNA methylation
Drugs			Clotrimazole Doxylamine Meclizine Loperamide Ketoconazole Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein (5BETA)-PREGNANE-3,20-DIONE Hexestrol Triclosan
Diseases
GWAS			Blood metabolite levels ( 24816252)
Interacting Genes		77 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	18 interacting genes: CHD9 DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC
Entrez ID		29947	9970
HPRD ID		09417	04858
Ensembl ID		ENSG00000142182	ENSG00000143257
Uniprot IDs		Q9UJW3	F1DAL4 Q14994
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57	1XV9 1XVP
Enriched GO Terms of Interacting Partners?
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