YAP1 and ENAH

Number of citations of the paper that reports this interaction (PubMedID 10358088)
16

Data Source:
BioGRID (pull down, affinity chromatography technology)

		YAP1	ENAH
Description		Yes1 associated transcriptional regulator	ENAH actin regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TEAD-1-YAP Complex TEAD-2-YAP Complex	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Proline-rich Region Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding WW Domain Binding
	Biological Process	Cell Morphogenesis Vasculogenesis Tissue Homeostasis Heart Process Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Progesterone Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Contact Inhibition Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Protein-containing Complex Assembly Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility
Pathways		Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
Drugs
Diseases
GWAS		Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 30566500 26416764) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Delirium ( 29631748) Depression in smokers ( 30219690) Neuroticism ( 27067015) Obesity-related traits ( 23251661)
Interacting Genes		33 interacting genes: ABL1 AKT1 ENAH ERBB4 HNRNPU KIF5A LATS2 LINC00839 NFE2 OTUD1 PRRG2 PTCH1 PTEN PTPN21 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP73 WBP1 WBP2 YWHAG YWHAQ YWHAZ	26 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP EVL FAT1 FYB1 GPHN HMGB1 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX
Entrez ID		10413	55740
HPRD ID		09424	12360
Ensembl ID		ENSG00000137693	ENSG00000154380
Uniprot IDs		A0A024R3E4 K0KVU2 P46937 Q86T74	A0A4D6J698 Q8N8S7
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X	2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG
Enriched GO Terms of Interacting Partners?
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