ENAH and APBB1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (x-ray crystallography, unspecified method, pull down)
HPRD (in vivo)

		ENAH	APBB1
Description		ENAH actin regulator	amyloid beta precursor protein binding family B member 1
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Protein-containing Complex Presynaptic Membrane Neuronal Cell Body Dendritic Spine Main Axon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Growth Cone Lamellipodium Growth Cone Filopodium
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding WW Domain Binding	Amyloid-beta Binding Chromatin Binding Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Protein-containing Complex Binding Tau Protein Binding Proline-rich Region Binding
	Biological Process	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Response To Iron Ion Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Delirium ( 29631748) Depression in smokers ( 30219690) Neuroticism ( 27067015) Obesity-related traits ( 23251661)	Blood protein levels ( 29875488)
Interacting Genes		26 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP EVL FAT1 FYB1 GPHN HMGB1 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX	68 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRKAR2A PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		55740	322
HPRD ID		12360	04087
Ensembl ID		ENSG00000154380	ENSG00000166313
Uniprot IDs		A0A4D6J698 Q8N8S7	B7Z4M9 O00213
PDB IDs		2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG	2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?