RAMP1 and IAPP

Number of citations of the paper that reports this interaction (PubMedID 10385705)
93

Data Source:
HPRD (in vitro)

		RAMP1	IAPP
Description		receptor activity modifying protein 1	islet amyloid polypeptide
Image
GO Annotations	Cellular Component	Extracellular Space Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Amylin Receptor Complex 1 CGRP Receptor Complex	Extracellular Region Extracellular Space Cell Neuronal Cell Body
	Molecular Function	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation
Drugs		Pramlintide	Copper
Diseases
GWAS		Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		6 interacting genes: CALCA CALCR CALCRL IAPP SLC31A2 VIPR1	6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2
Entrez ID		10267	3375
HPRD ID		05515	01005
Ensembl ID		ENSG00000132329	ENSG00000121351
Uniprot IDs		E9PC20 O60894	A0A024RAU1 P10997
PDB IDs		2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y	1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ
Enriched GO Terms of Interacting Partners?
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