DNAJB6 and USP8

Number of citations of the paper that reports this interaction (PubMedID 15342353)
12

Data Source:
HPRD (in vitro)

		DNAJB6	USP8
Description		DnaJ heat shock protein family (Hsp40) member B6	ubiquitin specific peptidase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Positive Regulation Of ATPase Activity Regulation Of Protein Localization Protein Localization To Nucleus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Organization Negative Regulation Of Transcription, DNA-templated Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus
Pathways		Regulation of HSF1-mediated heat shock response	Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
Drugs
Diseases
GWAS		Body mass index ( 28552196) Waist circumference ( 28552196)	Ankylosing spondylitis ( 30946743) Heel bone mineral density ( 30598549)
Interacting Genes		7 interacting genes: APP BRMS1 KRT18 MAP3K1 PIK3CA POLR1D USP8	40 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ
Entrez ID		10049	9101
HPRD ID		07107	04405
Ensembl ID		ENSG00000105993	ENSG00000138592
Uniprot IDs		A0A0J9YX62 O75190	A0A024R5S4 A8K8N5 P40818
PDB IDs		6U3R 6U3S	1WHB 2A9U 2GFO 2GWF 3N3K 6F09
Enriched GO Terms of Interacting Partners?
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