USP8 and H2AC20

Number of citations of the paper that reports this interaction (PubMedID 26507658)
14

Data Source:
BioGRID (enzymatic study)

		USP8	H2AC20
Description		ubiquitin specific peptidase 8	H2A clustered histone 20
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse	Nucleosome Nuclear Chromatin Nucleus Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding Cadherin Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus	Chromatin Organization Chromatin Silencing Biological_process
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Heel bone mineral density ( 30598549)
Interacting Genes		40 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	73 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 GATAD2A GATAD2B H2BC1 H2BC21 H3C1 H4C1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8
Entrez ID		9101	8338
HPRD ID		04405	09107
Ensembl ID		ENSG00000138592	ENSG00000184260
Uniprot IDs		A0A024R5S4 A8K8N5 P40818	Q16777
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09
Enriched GO Terms of Interacting Partners?
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