SMG6 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ASIC2	acid sensing ion channel subunit 2	Stimuli-sensing channels	Amiloride
Novel	CCL16	C-C motif chemokine ligand 16	Chemokine receptors bind chemokines G alpha (i) signalling events
Novel	CLUH	CLUH binding protein of NUMT mRNA
Novel	INPP5K	inositol polyphosphate-5-phosphatase K	Synthesis of PIPs at the plasma membrane
Novel	MRPL12	mitochondrial ribosomal protein L12	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control
Novel	PRPF8	pre-mRNA processing factor 8	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway		Retinitis pigmentosa (RP)
Novel	RAP1GAP2	RAP1 GTPase activating protein 2	Rap1 signalling
Novel	SNAI2	snail family transcriptional repressor 2	Regulation of PTEN gene transcription Regulation of PTEN gene transcription Negative Regulation of CDH1 Gene Transcription Transcriptional and post-translational regulation of MITF-M expression and activity		Waardenburg syndrome (WS) Piebaldism
	MEOX2	mesenchyme homeobox 2
	PPP1CC	protein phosphatase 1 catalytic subunit gamma	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
	RNF10	ring finger protein 10
	SMG5	SMG5 nonsense mediated mRNA decay factor	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
	TERT	telomerase reverse transcriptase	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	Zidovudine Grn163l Tertomotide	Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome

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