| Novel |
DEAF1
|
DEAF1 transcription factor |
|
|
|
| Novel |
MPI
|
mannose phosphate isomerase |
- Defective MPI causes MPI-CDG
- Synthesis of GDP-mannose
|
|
- Congenital disorders of glycosylation (CDG) type I
|
| Novel |
PXMP2
|
peroxisomal membrane protein 2 |
- Glyoxylate metabolism and glycine degradation
- Class I peroxisomal membrane protein import
|
|
|
| Novel |
TCF7
|
transcription factor 7 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- Deactivation of the beta-catenin transactivating complex
- Ca2+ pathway
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- Repression of WNT target genes
- Repression of WNT target genes
- RUNX3 regulates WNT signaling
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- Regulation of PD-L1(CD274) transcription
|
|
|
| Novel |
ZNF10
|
zinc finger protein 10 |
- Generic Transcription Pathway
|
|
|
| Novel |
ZNF26
|
zinc finger protein 26 |
- Generic Transcription Pathway
|
|
|
|
ATXN7
|
ataxin 7 |
- HATs acetylate histones
- Ub-specific processing proteases
|
|
- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
|
|
CASP2
|
caspase 2 |
- NOD1/2 Signaling Pathway
- NADE modulates death signalling
- TP53 Regulates Transcription of Caspase Activators and Caspases
|
|
|
|
CASP3
|
caspase 3 |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Apoptotic cleavage of cellular proteins
- SMAC, XIAP-regulated apoptotic response
- Apoptosis induced DNA fragmentation
- Degradation of the extracellular matrix
- Signaling by Hippo
- NADE modulates death signalling
- Stimulation of the cell death response by PAK-2p34
- Caspase-mediated cleavage of cytoskeletal proteins
- Apoptotic cleavage of cell adhesion proteins
- Caspase activation via Dependence Receptors in the absence of ligand
- Caspase activation via Dependence Receptors in the absence of ligand
- Other interleukin signaling
- Pyroptosis
- CASP4-mediated substrate cleavage
- CASP5-mediated substrate cleavage
|
- Pamidronic acid
- Acetylsalicylic acid
- Minocycline
- 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
- Emricasan
- Incadronic acid
- 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
- methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
- 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
- [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
- 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
- (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
- (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
- N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
- Tributyrin
- Oleandrin
- PAC-1
- Glycyrrhizic acid
|
|
|
CASP7
|
caspase 7 |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Apoptotic cleavage of cellular proteins
- SMAC, XIAP-regulated apoptotic response
- Caspase-mediated cleavage of cytoskeletal proteins
|
- Fica
- Emricasan
- Incadronic acid
|
|
|
FXR1
|
FMR1 autosomal homolog 1 |
- Signaling by BRAF and RAF1 fusions
|
|
|
|
GOLGA7
|
golgin A7 |
- Neutrophil degranulation
- RAS processing
- Maturation of spike protein
|
|
|
|
GOPC
|
golgi associated PDZ and coiled-coil motif containing |
- RHO GTPases regulate CFTR trafficking
- RHOQ GTPase cycle
|
|
|
|
KCNJ1
|
potassium inwardly rectifying channel subfamily J member 1 |
- Potassium transport channels
|
- Bethanidine
- Glimepiride
- Minoxidil
- Acetohexamide
- Ritodrine
- Tolbutamide
- Glymidine
- Yohimbine
- Agmatine
- Butamben
|
|
|
OLIG2
|
oligodendrocyte transcription factor 2 |
|
|
|
|
TSNAX
|
translin associated factor X |
- Small interfering RNA (siRNA) biogenesis
|
|
|