| Novel |
CDC7
|
cell division cycle 7 |
- Activation of ATR in response to replication stress
- Activation of the pre-replicative complex
- Transcriptional Regulation by E2F6
|
|
|
| Novel |
CTBS
|
chitobiase |
|
|
|
| Novel |
DOK1
|
docking protein 1 |
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- RET signaling
|
|
|
| Novel |
DPYD
|
dihydropyrimidine dehydrogenase |
|
- (5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione
- NADPH
- 6-Carboxymethyluracil
- Flavin adenine dinucleotide
- Flavin mononucleotide
- Uracil
- Eniluracil
- 5-Iodouracil
- Gimeracil
- Tegafur-uracil
|
- Dihydropyrimidine dehydrogenase deficiency
|
| Novel |
GCKR
|
glucokinase regulator |
- Regulation of Glucokinase by Glucokinase Regulatory Protein
- Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
|
|
|
| Novel |
GCNT1
|
glucosaminyl (N-acetyl) transferase 1 |
- O-linked glycosylation of mucins
|
|
|
| Novel |
GFI1
|
growth factor independent 1 transcriptional repressor |
- Transcriptional regulation of granulopoiesis
|
|
|
| Novel |
IGFBP5
|
insulin like growth factor binding protein 5 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Post-translational protein phosphorylation
|
|
|
| Novel |
KCNMB4
|
potassium calcium-activated channel subfamily M regulatory beta subunit 4 |
- Ca2+ activated K+ channels
- cGMP effects
|
- Procaine
- Ritodrine
- Nitrendipine
- Miconazole
- Colforsin
- Trimebutine
|
|
| Novel |
SH3GLB1
|
SH3 domain containing GRB2 like, endophilin B1 |
|
|
|
| Novel |
SLIT2
|
slit guidance ligand 2 |
- Netrin-1 signaling
- Signaling by ROBO receptors
- Signaling by ROBO receptors
- Activation of RAC1
- Regulation of commissural axon pathfinding by SLIT and ROBO
- Inactivation of CDC42 and RAC1
- Role of ABL in ROBO-SLIT signaling
- Role of ABL in ROBO-SLIT signaling
- SLIT2:ROBO1 increases RHOA activity
- Regulation of expression of SLITs and ROBOs
- Regulation of expression of SLITs and ROBOs
- Formation of the ureteric bud
|
|
|
| Novel |
SNRPB2
|
small nuclear ribonucleoprotein polypeptide B2 |
- mRNA Splicing - Major Pathway
|
|
|
| Novel |
WFS1
|
wolframin ER transmembrane glycoprotein |
- XBP1(S) activates chaperone genes
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Post-translational protein phosphorylation
|
|
- Wolfram syndrome (WFS); DIDMOAD syndrome
- Type II diabetes mellitus
|
|
ARHGAP5
|
Rho GTPase activating protein 5 |
- RHOA GTPase cycle
- RHOB GTPase cycle
- RHOC GTPase cycle
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RHOD GTPase cycle
- RHOQ GTPase cycle
- RHOG GTPase cycle
- RHOJ GTPase cycle
- RAC3 GTPase cycle
- RHOF GTPase cycle
- RND3 GTPase cycle
- RND2 GTPase cycle
- RND1 GTPase cycle
|
|
|
|
C11orf68
|
chromosome 11 open reading frame 68 |
|
|
|
|
CEBPA
|
CCAAT enhancer binding protein alpha |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
|
|
- Acute myeloid leukemia (AML)
|
|
ERBB2
|
erb-b2 receptor tyrosine kinase 2 |
- Signaling by ERBB2
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- PLCG1 events in ERBB2 signaling
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Downregulation of ERBB2:ERBB3 signaling
- GRB2 events in ERBB2 signaling
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Sema4D induced cell migration and growth-cone collapse
- RAF/MAP kinase cascade
- ERBB2 Regulates Cell Motility
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ERBB2 Activates PTK6 Signaling
- Downregulation of ERBB2 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Constitutive Signaling by Overexpressed ERBB2
- Drug-mediated inhibition of ERBB2 signaling
- Signaling by ERBB2 KD Mutants
- Resistance of ERBB2 KD mutants to trastuzumab
- Resistance of ERBB2 KD mutants to sapitinib
- Resistance of ERBB2 KD mutants to tesevatinib
- Resistance of ERBB2 KD mutants to neratinib
- Resistance of ERBB2 KD mutants to osimertinib
- Resistance of ERBB2 KD mutants to afatinib
- Resistance of ERBB2 KD mutants to AEE788
- Resistance of ERBB2 KD mutants to lapatinib
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
- Drug resistance in ERBB2 TMD/JMD mutants
- Developmental Lineage of Mammary Gland Luminal Epithelial Cells
- Developmental Lineage of Mammary Gland Myoepithelial Cells
- Developmental Lineage of Mammary Stem Cells
|
- Trastuzumab
- Lapatinib
- IGN311
- Trastuzumab emtansine
- Varlitinib
- AV-412
- Pertuzumab
- Afatinib
- Tucatinib
- Tesevatinib
- Fostamatinib
- Brigatinib
- Margetuximab
- Zanubrutinib
|
- Breast cancer
- Cervical cancer
- Cholangiocarcinoma
- Pancreatic cancer
- Gastric cancer
- Ovarian cancer
- Choriocarcinoma
- Endometrial Cancer
- Bladder cancer
|
|
FAM9B
|
family with sequence similarity 9 member B |
|
|
|
|
FOXP1
|
forkhead box P1 |
|
|
|
|
HID1
|
HID1 domain containing |
|
|
|