| Novel |
PCARE
|
photoreceptor cilium actin regulator |
|
|
- Retinitis pigmentosa (RP)
|
| Novel |
SPDYA
|
speedy/RINGO cell cycle regulator family member A |
|
|
|
| Novel |
TOGARAM2
|
TOG array regulator of axonemal microtubules 2 |
|
|
|
| Novel |
TRMT61B
|
tRNA methyltransferase 61B |
- tRNA modification in the mitochondrion
- Mitochondrial mRNA modification
|
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|
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APP
|
amyloid beta precursor protein |
- Platelet degranulation
- ECM proteoglycans
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (q) signalling events
- G alpha (i) signalling events
- Lysosome Vesicle Biogenesis
- Formyl peptide receptors bind formyl peptides and many other ligands
- TAK1-dependent IKK and NF-kappa-B activation
- The NLRP3 inflammasome
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Post-translational protein phosphorylation
- TRAF6 mediated NF-kB activation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Purinergic signaling in leishmaniasis infection
- Amyloid fiber formation
|
- Deferoxamine
- Aluminium
- Zinc
- L-methionine (R)-S-oxide
- Resveratrol
- Tromethamine
- Phenserine
- Tetrathiomolybdate
- CAD106
- Mito-4509
- Edonerpic
- Dimercaprol
- Copper
- Florbetaben (18F)
- Florbetapir (18F)
- Flutemetamol (18F)
- Gantenerumab
- Aducanumab
- Zinc acetate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
- Lecanemab
|
|
|
CDK5RAP2
|
CDK5 regulatory subunit associated protein 2 |
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- AURKA Activation by TPX2
|
|
- Primary microcephaly (MCPH)
|
|
CLIP1
|
CAP-Gly domain containing linker protein 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases activate IQGAPs
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
- Signaling by LTK in cancer
|
|
|
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CMYA5
|
cardiomyopathy associated 5 |
|
|
|
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DCAF6
|
DDB1 and CUL4 associated factor 6 |
|
|
|
|
DES
|
desmin |
- Striated Muscle Contraction
|
|
- Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
- Dilated cardiomyopathy (DCM)
- Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
- Scapuloperoneal myopathy (SPM)
|
|
DST
|
dystonin |
- Type I hemidesmosome assembly
- RHOU GTPase cycle
- RHOV GTPase cycle
- RND3 GTPase cycle
- RND2 GTPase cycle
- RND1 GTPase cycle
|
|
|
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DYNC2LI1
|
dynein cytoplasmic 2 light intermediate chain 1 |
|
|
|
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GLP1R
|
glucagon like peptide 1 receptor |
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- G alpha (s) signalling events
- Glucagon-type ligand receptors
|
- Glucagon
- Exenatide
- Liraglutide
- Albiglutide
- Dulaglutide
- Lixisenatide
- Semaglutide
- Taspoglutide
- Tirzepatide
- Efpeglenatide
- Glutazumab
|
|
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HSF2BP
|
heat shock transcription factor 2 binding protein |
|
|
|
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JAKMIP2
|
janus kinase and microtubule interacting protein 2 |
|
|
|
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KIF1B
|
kinesin family member 1B |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
|
|
- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
|
|
KIFC3
|
kinesin family member C3 |
|
|
|
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LZTS2
|
leucine zipper tumor suppressor 2 |
|
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|
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MAGEA12
|
MAGE family member A12 |
|
|
|
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MAP7
|
microtubule associated protein 7 |
|
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|