CKAP4 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	HCFC2	host cell factor C2	Formation of WDR5-containing histone-modifying complexes
Novel	PLXNC1	plexin C1	Other semaphorin interactions
Novel	POLR3B	RNA polymerase III subunit B	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Novel	PWP1	PWP1 homolog, endonuclein
Novel	RIC8B	RIC8 guanine nucleotide exchange factor B
Novel	SLC41A2	solute carrier family 41 member 2	Metal ion SLC transporters
Novel	WSCD2	WSC domain containing 2
	ASCC2	activating signal cointegrator 1 complex subunit 2	ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
	ATF4	activating transcription factor 4	ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating ER-stress associated genes	Pseudoephedrine
	DKK1	dickkopf Wnt signaling pathway inhibitor 1	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
	HAMP	hepcidin antimicrobial peptide			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
	LINC01554	long intergenic non-protein coding RNA 1554
	MLH1	mutL homolog 1	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination		Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer Endometrial Cancer
	MVP	major vault protein	Neutrophil degranulation
	NDUFB7	NADH:ubiquinone oxidoreductase subunit B7	Respiratory electron transport Complex I biogenesis	NADH
	NEIL3	nei like DNA glycosylase 3	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
	NKX3-1	NK3 homeobox 1			Prostate cancer
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes
	PLAT	plasminogen activator, tissue type	Signaling by PDGF Dissolution of Fibrin Clot	Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
	THOC7	THO complex subunit 7	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination

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