CKAP4 and RIC8B

		CKAP4	RIC8B
Description		cytoskeleton associated protein 4	RIC8 guanine nucleotide exchange factor B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lipid Droplet Cytoskeleton Plasma Membrane Membrane Nuclear Speck Azurophil Granule Membrane Specific Granule Membrane Lamellar Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Centrosome Cytosol Plasma Membrane Cell Cortex
	Molecular Function	RNA Binding Protein Binding	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Folding Chaperone
	Biological Process		Protein Folding G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Neutrophil degranulation Post-translational protein phosphorylation RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278)	Adiponectin levels ( 31178129) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Serum alkaline phosphatase levels ( 33547301 33339817) Severe influenza A (H1N1) infection ( 26379185) Social autistic-like traits ( 24133439) Triglyceride levels ( 32154731 32203549 29083408 28334899) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: ASCC2 ATF4 DKK1 HAMP LINC01554 MLH1 MVP NDUFB7 NEIL3 NKX3-1 OGT PLAT THOC7 TSNAX WASHC3	4 interacting genes: GNAQ GNAS KLHDC2 LRP1
Entrez ID		10970	55188
HPRD ID		16717	16452
Ensembl ID		ENSG00000136026	ENSG00000111785
Uniprot IDs		Q07065	B7WPL0 Q9NVN3
PDB IDs
Enriched GO Terms of Interacting Partners?			Response To Acidic PH Cellular Response To Acidic PH Guanyl Nucleotide Binding Cellular Response To PH G-protein Beta/gamma-subunit Complex Binding Response To Prostaglandin E Heterotrimeric G-protein Complex Response To PH G Protein Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Mu-type Opioid Receptor Binding Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Lipoprotein Particle Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Hair Follicle Placode Formation Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Positive Regulation Of Lysosomal Protein Catabolic Process Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Nuclear Membrane Response To Alcohol D1 Dopamine Receptor Binding Beta-2 Adrenergic Receptor Binding Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Lamellar Body Regulation Of Body Fluid Levels Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Wnt Signaling Pathway GTPase Activity Cellular Response To Glucagon Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Regulation Of Endocytosis Regulation Of Lysosomal Protein Catabolic Process
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