Search Results for: CFLAR

49 interactions involving CFLAR - CASP8 and FADD like apoptosis regulator found:

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Novel Symbol Description Pathways Hide Drugs Hide Diseases Hide
Novel ATF2 activating transcription factor 2
  • Transcriptional activation of mitochondrial biogenesis
  • HATs acetylate histones
  • Activation of the AP-1 family of transcription factors
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of PTEN gene transcription
  • Regulation of PTEN gene transcription
  • Estrogen-dependent gene expression
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • Heme signaling
  • Expression of BMAL (ARNTL), CLOCK, and NPAS2
  • Pseudoephedrine
Novel CAB39 calcium binding protein 39
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • Neutrophil degranulation
Novel CD28 CD28 molecule
  • PIP3 activates AKT signaling
  • Nef mediated downregulation of CD28 cell surface expression
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • Co-stimulation by CD28
  • CD28 dependent PI3K/Akt signaling
  • CD28 dependent Vav1 pathway
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Novel CRYGA crystallin gamma A
Novel ECE1 endothelin converting enzyme 1
  • Peptide ligand-binding receptors
  • 5-(2-hydroxyethyl)nonane-1,9-diol
Novel EEF1B2 eukaryotic translation elongation factor 1 beta 2
  • Eukaryotic Translation Elongation
Novel FGF13 fibroblast growth factor 13
  • Phase 0 - rapid depolarisation
Novel FZD5 frizzled class receptor 5
  • Class B/2 (Secretin family receptors)
  • Ca2+ pathway
  • Ca2+ pathway
  • Asymmetric localization of PCP proteins
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Regulation of FZD by ubiquitination
  • WNT5A-dependent internalization of FZD2, FZD5 and ROR2
  • Signaling by RNF43 mutants
Novel GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  • Association of TriC/CCT with target proteins during biosynthesis
  • Glycolysis
  • Gluconeogenesis
  • NADH
  • Zinc
  • (+)-Rutamarin alcohol
  • N-naphthalen-1-ylmethyl-2'-[3,5-dimethoxybenzamido]-2'-deoxy-adenosine
  • 2'-Deoxy-2'-[(3,5-dimethoxybenzoyl)amino]-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]adenosine
  • Artenimol
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
Novel GJA1 gap junction protein alpha 1
  • Oligomerization of connexins into connexons
  • Transport of connexins along the secretory pathway
  • Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
  • Gap junction assembly
  • Gap junction assembly
  • Gap junction degradation
  • Regulation of gap junction activity
  • Regulation of gap junction activity
  • Formation of annular gap junctions
  • RHOQ GTPase cycle
  • RHOJ GTPase cycle
  • SARS-CoV-2 targets PDZ proteins in cell-cell junction
  • Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
  • Carvedilol
  • Deafness, autosomal recessive
  • Oculodentodigital dysplasia
  • Syndactyly
Novel KCNIP3 potassium voltage-gated channel interacting protein 3
  • Phase 1 - inactivation of fast Na+ channels
  • Regulation of NPAS4 gene transcription
Novel MYL1 myosin light chain 1
  • Striated Muscle Contraction
Novel NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1
  • Respiratory electron transport
  • Complex I biogenesis
  • Mitochondrial protein degradation
  • NADH
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
Novel PROC protein C, inactivator of coagulation factors Va and VIIIa
  • Intrinsic Pathway of Fibrin Clot Formation
  • Common Pathway of Fibrin Clot Formation
  • Gamma-carboxylation of protein precursors
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
  • Cell surface interactions at the vascular wall
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Menadione
  • Sodium tetradecyl sulfate
  • Cupric Chloride
  • Kappadione
  • Protein S human
  • Inherited thrombophilia
Novel QPCT glutaminyl-peptide cyclotransferase
  • Neutrophil degranulation
  • 1-benzylimidazole
  • N-acetylhistamine
  • Glutamine t-butyl ester
BCL2L1 BCL2 like 1
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • Interleukin-4 and Interleukin-13 signaling
  • The NLRP1 inflammasome
  • RAS processing
  • SARS-CoV-1-mediated effects on programmed cell death
  • STAT5 activation downstream of FLT3 ITD mutants
  • NFE2L2 regulating tumorigenic genes
  • 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
  • Gossypol
CASP10 caspase 10
  • TP53 Regulates Transcription of Caspase Activators and Caspases
  • FasL/ CD95L signaling
  • TRAIL signaling
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
CASP2 caspase 2
  • NOD1/2 Signaling Pathway
  • NADE modulates death signalling
  • TP53 Regulates Transcription of Caspase Activators and Caspases
CASP3 caspase 3
  • Activation of caspases through apoptosome-mediated cleavage
  • SMAC (DIABLO) binds to IAPs
  • SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
  • Apoptotic cleavage of cellular proteins
  • SMAC, XIAP-regulated apoptotic response
  • Apoptosis induced DNA fragmentation
  • Degradation of the extracellular matrix
  • Signaling by Hippo
  • NADE modulates death signalling
  • Stimulation of the cell death response by PAK-2p34
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Apoptotic cleavage of cell adhesion proteins
  • Caspase activation via Dependence Receptors in the absence of ligand
  • Caspase activation via Dependence Receptors in the absence of ligand
  • Other interleukin signaling
  • Pyroptosis
  • CASP4-mediated substrate cleavage
  • CASP5-mediated substrate cleavage
  • Pamidronic acid
  • Acetylsalicylic acid
  • Minocycline
  • 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
  • Emricasan
  • Incadronic acid
  • 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
  • methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
  • 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
  • [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
  • 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
  • (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
  • (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
  • N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
  • Tributyrin
  • Oleandrin
  • PAC-1
  • Glycyrrhizic acid
CASP6 caspase 6
  • Apoptotic cleavage of cellular proteins
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Breakdown of the nuclear lamina
  • TP53 Regulates Transcription of Caspase Activators and Caspases

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