| Novel |
ANXA7
|
annexin A7 |
|
|
|
| Novel |
CAMK2G
|
calcium/calmodulin dependent protein kinase II gamma |
- CaMK IV-mediated phosphorylation of CREB
- HSF1-dependent transactivation
- Trafficking of AMPA receptors
- Unblocking of NMDA receptors, glutamate binding and activation
- Unblocking of NMDA receptors, glutamate binding and activation
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
- Ras activation upon Ca2+ influx through NMDA receptor
- Phase 0 - rapid depolarisation
- Ion homeostasis
- RAF activation
- RAF/MAP kinase cascade
- Signaling by moderate kinase activity BRAF mutants
- Signaling by BRAF and RAF1 fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Interferon gamma signaling
- Regulation of MECP2 expression and activity
- Ion transport by P-type ATPases
- Assembly and cell surface presentation of NMDA receptors
- Negative regulation of NMDA receptor-mediated neuronal transmission
- Long-term potentiation
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
|
- Bosutinib
- 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Fostamatinib
|
|
| Novel |
CCND2
|
cyclin D2 |
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- Drug-mediated inhibition of CDK4/CDK6 activity
|
|
|
| Novel |
LZTS1
|
leucine zipper tumor suppressor 1 |
|
|
|
| Novel |
NRBF2
|
nuclear receptor binding factor 2 |
|
|
|
| Novel |
RHOBTB1
|
Rho related BTB domain containing 1 |
|
|
|
| Novel |
RIOX2
|
ribosomal oxygenase 2 |
- HDMs demethylate histones
- Protein hydroxylation
|
|
|
| Novel |
SLC22A1
|
solute carrier family 22 member 1 |
- Neurotransmitter clearance
- Norepinephrine Neurotransmitter Release Cycle
- Abacavir transmembrane transport
- SLC-mediated transport of neurotransmitters
- SLC-mediated transport of organic cations
- Ciprofloxacin ADME
|
|
|
| Novel |
USP54
|
ubiquitin specific peptidase 54 |
|
|
|
|
RUNX1
|
RUNX family transcription factor 1 |
- Pre-NOTCH Transcription and Translation
- SLC-mediated transport of organic cations
- RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
- RUNX1 regulates estrogen receptor mediated transcription
- Regulation of RUNX1 Expression and Activity
- Regulation of RUNX1 Expression and Activity
- RUNX1 regulates expression of components of tight junctions
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
- RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- RUNX1 regulates transcription of genes involved in BCR signaling
- RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
- RUNX1 regulates transcription of genes involved in interleukin signaling
- RUNX1 regulates transcription of genes involved in WNT signaling
- RUNX2 regulates genes involved in differentiation of myeloid cells
- RUNX3 regulates p14-ARF
- Estrogen-dependent gene expression
- Transcriptional regulation of granulopoiesis
- SARS-CoV-1 activates/modulates innate immune responses
- Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
|
|
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
- Acute myeloid leukemia (AML)
- Chronic myeloid leukemia (CML)
- Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
|