Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols HSPB1 and SLC7A9	Name 1 heat shock protein family B (small) member 1	Name2 solute carrier family 7 member 9	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 Basigin interactions Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU)	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2 Cystinuria
Novel Novel	Symbols HSPB1 and PSMB2	Name 1 heat shock protein family B (small) member 1	Name2 proteasome 20S subunit beta 2	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel Novel	Symbols HSPB1 and PTPN3	Name 1 heat shock protein family B (small) member 1	Name2 protein tyrosine phosphatase non-receptor type 3	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 EGFR downregulation Negative regulation of MAPK pathway	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel Novel	Symbols HSPB1 and TTC39C	Name 1 heat shock protein family B (small) member 1	Name2 tetratricopeptide repeat domain 39C	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel Novel	Symbols HSPB1 and ZNRF3	Name 1 heat shock protein family B (small) member 1	Name2 zinc and ring finger 3	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 Regulation of FZD by ubiquitination	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel Novel	Symbols PTPN11 and FCRL3	Name 1 protein tyrosine phosphatase non-receptor type 11	Name2 Fc receptor like 3	Pathway 1 Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Co-inhibition by CTLA4 Co-inhibition by PD-1 Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants SARS-CoV-2 activates/modulates innate and adaptive immune responses Co-inhibition by BTLA	Pathway 2	Drugs 1 Dodecyltrimethylammonium	Drugs 2	Diseases 1 Metachondromatosis Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Diseases 2
Novel Novel	Symbols GFI1 and PIAS3	Name 1 growth factor independent 1 transcriptional repressor	Name2 protein inhibitor of activated STAT 3	Pathway 1 Transcriptional regulation of granulopoiesis	Pathway 2 SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols EPS15 and TMEM114	Name 1 epidermal growth factor receptor pathway substrate 15	Name2 transmembrane protein 114	Pathway 1 EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KCNB1 and KCNG2	Name 1 potassium voltage-gated channel subfamily B member 1	Name2 potassium voltage-gated channel modifier subfamily G member 2	Pathway 1 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Pathway 2 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Drugs 1 Enflurane Promethazine Miconazole Dalfampridine	Drugs 2 Enflurane Promethazine Miconazole	Diseases 1	Diseases 2
Novel Novel	Symbols KCNB1 and KCNG1	Name 1 potassium voltage-gated channel subfamily B member 1	Name2 potassium voltage-gated channel modifier subfamily G member 1	Pathway 1 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Pathway 2 Voltage gated Potassium channels	Drugs 1 Enflurane Promethazine Miconazole Dalfampridine	Drugs 2 Enflurane Promethazine Miconazole	Diseases 1	Diseases 2
Novel Novel	Symbols KCNB1 and KCNB2	Name 1 potassium voltage-gated channel subfamily B member 1	Name2 potassium voltage-gated channel subfamily B member 2	Pathway 1 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Pathway 2 Voltage gated Potassium channels	Drugs 1 Enflurane Promethazine Miconazole Dalfampridine	Drugs 2 Enflurane Promethazine Miconazole Dalfampridine	Diseases 1	Diseases 2
Novel Novel	Symbols UBE2I and PPM1J	Name 1 ubiquitin conjugating enzyme E2 I	Name2 protein phosphatase, Mg2+/Mn2+ dependent 1J	Pathway 1 Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SARS-CoV-1 targets host intracellular signalling and regulatory pathways SUMOylation of nuclear envelope proteins PKR-mediated signaling Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols DTNB and FAM167A	Name 1 dystrobrevin beta	Name2 family with sequence similarity 167 member A	Pathway 1 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GNG7 and GNB5	Name 1 G protein subunit gamma 7	Name2 G protein subunit beta 5	Pathway 1 Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Pathway 2 Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PHC2 and SFMBT1	Name 1 polyhomeotic homolog 2	Name2 Scm like with four mbt domains 1	Pathway 1 Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PPP1CA and LPIN2	Name 1 protein phosphatase 1 catalytic subunit alpha	Name2 lipin 2	Pathway 1 Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Synthesis of PC Synthesis of PE Depolymerization of the Nuclear Lamina Triglyceride biosynthesis	Drugs 1 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Drugs 2	Diseases 1	Diseases 2 Majeed syndrome; Chronic recurrent multifocal osteomyelitis (CRMO)
Novel Novel	Symbols PPP1CA and KNL1	Name 1 protein phosphatase 1 catalytic subunit alpha	Name2 kinetochore scaffold 1	Pathway 1 Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Drugs 1 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PPP1CA and KIF18A	Name 1 protein phosphatase 1 catalytic subunit alpha	Name2 kinesin family member 18A	Pathway 1 Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins Kinesins	Drugs 1 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols POLR2G and RPAP1	Name 1 RNA polymerase II subunit G	Name2 RNA polymerase II associated protein 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ABHD16A and GDAP1	Name 1 abhydrolase domain containing 16A, phospholipase	Name2 ganglioside induced differentiation associated protein 1	Pathway 1	Pathway 2 Class I peroxisomal membrane protein import	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols HSPB1 and SLC7A9	Name 1 heat shock protein family B (small) member 1	Name2 solute carrier family 7 member 9	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 Basigin interactions Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU)	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2 Cystinuria
Novel	Symbols HSPB1 and PSMB2	Name 1 heat shock protein family B (small) member 1	Name2 proteasome 20S subunit beta 2	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel	Symbols HSPB1 and PTPN3	Name 1 heat shock protein family B (small) member 1	Name2 protein tyrosine phosphatase non-receptor type 3	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 EGFR downregulation Negative regulation of MAPK pathway	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel	Symbols HSPB1 and TTC39C	Name 1 heat shock protein family B (small) member 1	Name2 tetratricopeptide repeat domain 39C	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel	Symbols HSPB1 and ZNRF3	Name 1 heat shock protein family B (small) member 1	Name2 zinc and ring finger 3	Pathway 1 VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Pathway 2 Regulation of FZD by ubiquitination	Drugs 1 Apatorsen Artenimol Phenethyl Isothiocyanate	Drugs 2	Diseases 1 Distal hereditary motor neuropathies (dHMN)	Diseases 2
Novel	Symbols PTPN11 and FCRL3	Name 1 protein tyrosine phosphatase non-receptor type 11	Name2 Fc receptor like 3	Pathway 1 Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Co-inhibition by CTLA4 Co-inhibition by PD-1 Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants SARS-CoV-2 activates/modulates innate and adaptive immune responses Co-inhibition by BTLA	Pathway 2	Drugs 1 Dodecyltrimethylammonium	Drugs 2	Diseases 1 Metachondromatosis Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Diseases 2
Novel	Symbols GFI1 and PIAS3	Name 1 growth factor independent 1 transcriptional repressor	Name2 protein inhibitor of activated STAT 3	Pathway 1 Transcriptional regulation of granulopoiesis	Pathway 2 SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols EPS15 and TMEM114	Name 1 epidermal growth factor receptor pathway substrate 15	Name2 transmembrane protein 114	Pathway 1 EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KCNB1 and KCNG2	Name 1 potassium voltage-gated channel subfamily B member 1	Name2 potassium voltage-gated channel modifier subfamily G member 2	Pathway 1 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Pathway 2 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Drugs 1 Enflurane Promethazine Miconazole Dalfampridine	Drugs 2 Enflurane Promethazine Miconazole	Diseases 1	Diseases 2
Novel	Symbols KCNB1 and KCNG1	Name 1 potassium voltage-gated channel subfamily B member 1	Name2 potassium voltage-gated channel modifier subfamily G member 1	Pathway 1 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Pathway 2 Voltage gated Potassium channels	Drugs 1 Enflurane Promethazine Miconazole Dalfampridine	Drugs 2 Enflurane Promethazine Miconazole	Diseases 1	Diseases 2
Novel	Symbols KCNB1 and KCNB2	Name 1 potassium voltage-gated channel subfamily B member 1	Name2 potassium voltage-gated channel subfamily B member 2	Pathway 1 Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Pathway 2 Voltage gated Potassium channels	Drugs 1 Enflurane Promethazine Miconazole Dalfampridine	Drugs 2 Enflurane Promethazine Miconazole Dalfampridine	Diseases 1	Diseases 2
Novel	Symbols UBE2I and PPM1J	Name 1 ubiquitin conjugating enzyme E2 I	Name2 protein phosphatase, Mg2+/Mn2+ dependent 1J	Pathway 1 Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SARS-CoV-1 targets host intracellular signalling and regulatory pathways SUMOylation of nuclear envelope proteins PKR-mediated signaling Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols DTNB and FAM167A	Name 1 dystrobrevin beta	Name2 family with sequence similarity 167 member A	Pathway 1 Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GNG7 and GNB5	Name 1 G protein subunit gamma 7	Name2 G protein subunit beta 5	Pathway 1 Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Pathway 2 Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PHC2 and SFMBT1	Name 1 polyhomeotic homolog 2	Name2 Scm like with four mbt domains 1	Pathway 1 Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PPP1CA and LPIN2	Name 1 protein phosphatase 1 catalytic subunit alpha	Name2 lipin 2	Pathway 1 Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Synthesis of PC Synthesis of PE Depolymerization of the Nuclear Lamina Triglyceride biosynthesis	Drugs 1 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Drugs 2	Diseases 1	Diseases 2 Majeed syndrome; Chronic recurrent multifocal osteomyelitis (CRMO)
Novel	Symbols PPP1CA and KNL1	Name 1 protein phosphatase 1 catalytic subunit alpha	Name2 kinetochore scaffold 1	Pathway 1 Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Drugs 1 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PPP1CA and KIF18A	Name 1 protein phosphatase 1 catalytic subunit alpha	Name2 kinesin family member 18A	Pathway 1 Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Pathway 2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins Kinesins	Drugs 1 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols POLR2G and RPAP1	Name 1 RNA polymerase II subunit G	Name2 RNA polymerase II associated protein 1	Pathway 1 Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ABHD16A and GDAP1	Name 1 abhydrolase domain containing 16A, phospholipase	Name2 ganglioside induced differentiation associated protein 1	Pathway 1	Pathway 2 Class I peroxisomal membrane protein import	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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